Objective: The impact of Coronavirus disease (COVID-19) among children, appears to be milder with a significantly lower mortality rate and 1-5% of global pediatric population was identified with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This review article focuses on the potential health benefits of black seeds (Nigella Sativa) in the management of children with COVID-19.

Materials and Methods: The literature was looked in databases such as Medline/PubMed Central/PubMed, Google Scholar, bioRxiv, medRxiv, Science Direct, EBSCO, Scopus, Web of Science, EMBASE, Directory of Open Access Journals (DOAJ), and reference lists to identify published manuscripts relevant to the use of black seeds (N. sativa) to treat COVID-19 in children.

Results: Numerous clinical studies and in-silico molecular docking studies were performed to determine the potential beneficial effects of N. sativa in COVID-19 management. In addition, various clinical studies demonstrated the antiviral, antioxidant, anti-inflammatory and other pharmacological effects of N. sativa. Moreover, various clinical studies proved the safety of Black seeds (N. sativa) in pediatric population.

Conclusions: Children with COVID-19 may use N. sativa seeds or oil as an adjunctive therapy along with standard care, to prevent MIS-C like consequences, and hospitalizations. Randomized controlled clinical trials specifically in COVID-19 children would further establish the safety and efficacy of N. sativa.