Objective: Discontinuation and poor compliance are leading causes of oral contraception failure. Because of possible adverse effects that impact their quality of life, women skip their daily dose of contraceptive, or opt for different contraception methods. This study aims to assess whether a specifically formulated dietary supplement helps to reduce the occurrence of these unwanted side effects in women prescribed an estroprogestinic contraceptive.

Patients and Methods: This is a controlled pilot prospective study, involving 52 healthy female volunteers who were prescribed an estroprogestinic contraceptive. The study group (n=26) received a dietary supplement containing Centella Asiatica (C.A.) extract, vitamins and minerals, the control group (n=26) received only the estroprogestinic pill. Baseline values were measured at enrollment, and the outcomes assessed after 3 months of intervention. Bodyweight, BMI and extracellular body water were measured with a bioelectrical impedance analysis (BIA) scale. Evaluation of cellulite, breast tenderness, leg swelling, mood, fatigue, migraine, vaginal discharge and hair dryness was self-reported by patients through a dedicated questionnaire.

Results: After 3 months of supplementation, patients reported a noticeable 56% decrease in cellulite level and a 4% decrease in water retention with respect to the control group. Significant improvements were observed also for the remaining outcomes. Overall, supplementation counteracts the negative effect the estroprogestinic contraceptive by significantly limiting water retention, bodyweight and BMI increase. Moreover, all other outcomes improved compared to both control group and baseline values.

Conclusions: The results of this study indicate that specific supplementation significantly limits frequency and severity of adverse effects during oral contraception therapy. C.A. extract helps to reduce water retention, counteracting the consequent bodyweight increase, leg swelling and breast tenderness. The combination of vitamins and minerals contributes to the reduced occurrence of migraine, increased energy levels, and to a generally better mood.