Objective: Endocrine and metabolic functions are altered during pregnancy to provide for the demands of the fetus, leading to an unbalance of the normal biochemical values. Subclinical hypothyroidism (SCH) is a common pregnancy-related thyroid disorder, in which fluctuations of thyroid-stimulating hormone (TSH) are recorded over the upper limit. The aim of this study was to evaluate the subclinical fluctuations of thyroid hormones throughout gestation and to maintain the euthyroid state in all pregnant women, as recommended by the ATA/AACE Guidelines.
Patients and Methods: 33 pregnant women meeting the inclusion criteria were included in the study and divided in 2 groups: one group following a treatment with MI + Se from 1st visit throughout pregnancy and the 2nd group in which no treatment was prescribed. Primary outcome was serum TSH and second outcomes were fT3, fT4 levels, type of delivery and neonatal complications.
Results: Normal thyroid hormones values were maintained in 94.1% of pregnant women in the treated group, compared to 68.7% in the control group.
Conclusions: The present study corroborates our previous finding, proving that, the combined treatment, MI + Se is effective in maintaining the values of TSH, fT3 and fT4, thus preventing SCH.