Effects of riboflavin and cobalamin levels on maternal metabolic homeostasis: a possible strategy to prevent gestational diabetes mellitus?

IJMDAT 2018; 1 (1) : e120

Laganà A. S.

Department of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, Varese, Italy
antlagana@unime.it Close

, Chiofalo B.

Department of Experimental Clinical Oncology, Gynecologic Oncology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy Close

, Gullo G.

Department of Human Pathology in Adulthood and Childhood “G. Barresi”, Unit of Gynecology and Obstetrics, University of Messina, Messina, Italy Close

, Corica S.

Department of Gynecology and Obstetrics, “Villa Elisa” Private Clinic, Cinquefrondi, Reggio Calabria, Italy Close

Abstract

Riboflavin deficiency increases body weight and fat deposition and decreases Glucose Transporter Type 4 (GLUT-4) and Glucokinase (GCK) expression. Cobalamin deficiency inhibits the conversion of methylmalonic acid (MMA) to succinyl-coA, causing MMA overload and consequent induction of lipogenesis and insulin resistance; in addition, it reduces the methylation of homocysteine to methionine, causing the accumulating of homocysteine which further enhances insulin resistance. Both riboflavin and cobalamin may prevent the onset of Gestational Diabetes Mellitus (GDM) in pregnant women.

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